Methylxanthine are commonly used for treatment of asthma and other respiratory system disorder. They consist of three members; caffeine, theophylline and theobromine.\r\nAntidermatophytic activity of methylxanthine after addition of adenine and guanine was determined against two clinically isolates of dermatophytes including Trichophyton mentagrophytes and Epidermophyton floccosum. Measurement of colony diameter that converted to percentage inhibition was the main method used in this study.\r\nAdenine at lower concentrations increased inhibitory effects of methylxanthine on two strains of dermatophytes. Meanwhile, high concentrations of guanine exhibited the same results. Epidermophyton floccosum showed more susceptibility to the mixture of methylxanthine with guanine than those of Trichophyton mentagrophytes.\r\nIn conclusions: The ability of methylxanthine to inhibit dermatophytes growth had been increased in the presence of adenine and guanine.
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